FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO DE LA PRINCESA
发明人:
LEON MARTINEZ, RAFAEL,BUENDIA ABAITUA, IZASKUN,NAVARRO GONZALEZ DE MESA, ELISA,MICHALSKA, PATRYCJA,GAMEIRO ROS, ISABEL,EGEA MAIQUEZ, JAVIER,GARCIA LOPEZ, MANUELA,GARCIA GARCIA, ANTONIO,LOPEZ VIVO, ALI
申请号：
CA2964309
公开号：
CA2964309A1
申请日:
2015.10.15
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention relates to the methods for producing derivatives of 3-alkylamino-1H-indole acrylate (I) with transcription factor Nrf2-inducing activity, free radical scavenging activity and neuroprotective ability. The invention also relates to the use of the derivatives according to the invention for the treatment of diseases, the pathogenesis of which involves oxidative stress, or diseases involving the deregulation of the activity of phase II genes activated by the factor Nrf2, such as Alzheimers disease, Parkinsons disease, Huntingtons disease, multiple sclerosis, ictus or amyotrophic lateral sclerosis.
