Guangxin XIA,Di LI,Ning ZHOU,Ao CHEN,Liang ZHAO,Jiansheng HAN,Yanjun LIU
申请号：
US16335622
公开号：
US20190300491A1
申请日:
2017.09.22
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture.
