The present invention includes a first therapy comprising administering to an individual an effective amount of a taxane of a nanoparticle composition and administration of an effective amount of at least one other agent that antagonizes the PD-1 pathway of the cell. A combination therapy for treating a proliferative disease (such as cancer) is provided including a second therapy obtained. [Selection] Figure 1本発明は、ナノ粒子組成物の有効量のタキサンを個体に投与することを含む第１の療法と、細胞のＰＤ－１経路に拮抗する有効量の少なくとも１つの他の作用物質の投与を含み得る第２の療法とを含む、増殖性疾患（がんなど）を治療する併用療法を提供する。【選択図】図１
