HIGHLY SOLUBLE AQUAPORIN-4 EXTRACELLULAR LOOP C PEPTIDE IMMUNIZATION FOR TREATMENT OF NEUROMYELITIS OPTICA

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专利权人:

THE JOHNS HOPKINS UNIVERSITY

发明人:

Michael Levy

申请号：

US15312368

公开号：

US20170080063A1

申请日:

2015.05.19

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention provides pharmaceutical compositions for treating neuromyelitis optica (NMO) comprising a therapeutically effective amount of loop C sequence-containing peptide of aquaporin-4 (AQP4) water channel, or a therapeutically effective fragment or variant thereof. The invention also provides methods for treating NMO by administering therapeutically effective amounts of loop C sequence-containing peptide(s) of AQP4, optionally in an immunosuppressive setting, and also provides diagnostics for detection of NMO in a subject, screening methods for identification of NMO-treating therapeutics and NMO model systems.

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