HAUSER, CHARLOTTE,LOO, YIHUA,WAN, ANDREW C. A.,REITHOFER, MICHAEL
申请号：
SG11201401964T
公开号：
SG11201401964TA
申请日:
2012.11.05
申请国别(地区):
SG
年份:
2014
代理人:
摘要：
The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z&mdash；(X)m&mdash；(Y)n&mdash；Z&prime；p, wherein Z is an N-terminal protecting group； X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine； Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative； Z&prime； is a C-terminal protecting group； m is an integer selected from 2 to 6； n is selected from 1 or 2； and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.
