The present invention relates to the combination of β - lactamase inhibitor, sulbactam and optional imipenem / cilastatin. The combination is suitable for the treatment of bacterial infections, including infections caused by drug-resistant organisms including multidrug-resistant pathogens. More specifically, the present invention relates to a combination of a β - lactamase inhibitor compound 1 or its pharmaceutically acceptable salt and sulbactam or its pharmaceutically acceptable salt and optional imipenem / cilastatin or pharmaceutically acceptable salt thereof.本發明涉及β‑內酰胺酶抑制劑與舒巴坦及任選的亞胺培南／西司他丁的組合。所述組合適用於治療細菌感染，包括由包括多重耐藥性病原體的耐藥性生物體所引起的感染。更具體地說，本發明涉及β‑內酰胺酶抑制劑化合物1或其藥學上可接受的鹽與舒巴坦或其藥學上可接受的鹽及任選的亞胺培南／西司他丁或其藥學上可接受的鹽的組合。
