The present invention is directed to combinations of a β-lactamase inhibitor with sulbactam and, optionally, imipenem/cilastatin. The combinations are useful for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant pathogens. More particularly, the invention relates to a combination of β-lactamase inhibitor compound 1: or a pharmaceutically acceptable salt thereof, with sulbactam, or a pharmaceutically acceptable salt thereof, and, optionally, imipenem/cilastatin, or a pharmaceutically acceptable salt thereof.本發明係關於β-內醯胺酶抑制劑與舒巴坦(sulbactam)及視情況存在之亞胺培南(imipenem)/西司他丁(cilastatin)的組合。該等組合適用於治療細菌感染,包括由抗藥性生物體,包括多重抗藥性病原體引起之感染。更特定而言,本發明係關於β-內醯胺酶抑制劑化合物1:或其醫藥學上可接受之鹽與舒巴坦或其醫藥學上可接受之鹽及視情況存在之亞胺培南/西司他丁或其醫藥學上可接受之鹽的組合。
