ВУД Дэниел Гай (GB),ДЖОНС Стюарт Аллен (GB),БРАУН Марк Барри (GB)
申请号：
RU2014101690/15
公开号：
RU2014101690A
申请日:
2012.06.22
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. Thermogenic composition for use in the transdermal administration of a medicament, wherein said medicament is present in said composition or the second composition of one or more permeation enhancers ability present in one or both of the compositions and wherein at least one penetrating power amplifier is C -compound containing at least one group -Alk-O-, wherein Alk is C-alkylene and if there is only one group -Alk-O-, then Alk may also be a C-alkyl group. 2. Composition according to Claim. 1, wherein said composition comprises a thermogenic supercooled salt rastvor.3. Composition according to Claim. 1, wherein the thermogenic composition is prepared in situ or immediately before use by combining a solvent, preferably water, at least one anhydrous salt, capable of releasing heat during hydration of the salt is preferably selected from the anhydrous form of calcium chloride salts (CaCl) and magnesium sulfate (MgSO) .4. Composition according to Claim. 1, wherein said composition comprises a thermogenic monomers capable of releasing heat during the polymerization after addition of a suitable catalyst, the monomers are preferably bisphenol-A (BPA) and epichlorohydrin (UST) .5. Composition according to Claim. 1, where a thermogenic composition capable of reaching temperatures at least 40 ° C, and preferably not more than 50 ° C.6. Composition according to Claim. 5, where the thermogenic composition adapted to achieve a temperature from 42 ° C to 45 ° C vklyuchitelno.7. Composition according to Claim. 5 or 6 wherein the thermogenic composition adapted to maintain a temperature above 32 ° C for at least 5 minutes, preferably at least 10 minutes and preferably in tech1. Термогенный состав для применения в трансдермальном введении лекарственного средства, где указанное лекарственное средство присутствует в указанном составе или во втором составе, один или несколько усилителей проникающей способности, присутствующие в одном или обоих составах, и где по меньшей мере один у
