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PEPTIDES OR PEPTIDIC CONJUGATE DERIVATIVES OF MSH AND THE USE THEREOF FOR COSMETICALLY FIGHTING AGAINST CANITIES
专利权人:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);INSTITUT EUROPEEN DE BIOLOGIE CELLULAIRE;UNIVERSITE MONTPELLIER II;UNIVERSITE DE MONTPELLIER I
发明人:
HOCQUAUX, MICHEL,PINEL, ANNE-MARIE,MARTINEZ, JEAN,SUBRA, GILLES
申请号:
CA2566481
公开号:
CA2566481C
申请日:
2005.05.10
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The present invention relates to a peptide corresponding to the formula (I) W-DPhe-Arg ~ Z (I) and its peptide conjugate corresponding to the formula (II) AW-DPhe-Arg-Z (II) in which: A represents the radical corresponding to a monocarboxylic acid of general formula (III) HOOC-R (III) in which R represents a C 1 -C 24 aliphatic radical, linear or branched, optionally substituted with a hydroxyl group, which may comprise one or more unsaturations, advantageously of 1 to 6 unsaturations, lipoic acid or its reduced form dihydrolipoic acid, N-lipoyl-lysine, or phenylbutyric acid W represents His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg, Nle-Ala-Arg, Nle-Ala-DTrp or a bond in the case of the compounds of formula II, Z represents NH2, OH, OR in which R represents a linear or branched C1-C24 aliphatic radical, TrpNH2, N apNH2, TpiNH2, TicNH2, AlaNH2i TrpOH, NapOH, TpiOH, TicOH, AlaOH, PheNH2, or PheOH, with the exception of the peptide conjugate for which A represents the radical corresponding to acetic acid, W represents Nle-Ala-His and Z represents TrpNH2, as enantiomers or diastereoisomers, and mixtures thereof, including racemic mixtures. The present invention further relates to the use of these compounds in the cosmetic treatment of canities.La présente invention concerne un peptide répondant à la formule (I) W-DPhe-Arg~ Z (I) et son conjugué peptidique répondant à la formule (II) A-W-DPhe-Arg-Z (II) dans lesquelles : A représente le radical correspondant à un acidemonocarboxylique de formule générale (III) HOOC-R (III) dans laquelle Rreprésente un radical aliphatique en C1-C24, linéaire ou ramifié,éventuellement substitué par un groupe hydroxy, pouvant comporter une ouplusieurs insaturations, avantageusement de 1 à 6 insaturations, l'acidelipoïque ou sa forme réduite l'acide dihydrolipoïque, la N-lipoyl-lysine, oul'acide phénylbutyrique W r
来源网站:
中国工程科技知识中心
来源网址:
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