There is provided a medical observation apparatus including: an imaging control section that controls a zoom function of an imaging device on a basis of a first toggle operation that toggles from a mode that controls an optical zoom to a mode that controls an electronic zoom. The imaging control section controls the zoom function so that the electronic zoom is executed on a predetermined region in a medical captured image captured by the imaging device, at an optical magnification of an optical system of the imaging device corresponding to when the first toggle operation was detected.