FACTOR VIII WITH EXTENDED HALF-LIFE AND REDUCED LIGAND-BINDING PROPERTIES

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专利权人:

Baxalta Incorporated;Baxalta GmbH

发明人:

Peter Turecek,Gerald Schrenk,Juergen Siekmann

申请号：

US16283525

公开号：

US20190240295A1

申请日:

2019.02.22

申请国别(地区):

US

年份:

2019

代理人:

摘要：

The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to a modified, recombinant Factor VIII (FVIII) with extended half-life and reduced ligand-binding properties.

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中国工程科技知识中心

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http://www.ckcest.cn/home/