Factor VIII with extended half-life and reduced ligand-binding properties

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专利权人:

Baxalta Incorporated;Baxalta GmbH

发明人:

Turecek, Peter,Schrenk, Gerald,Siekmann, Juergen

申请号：

AU2016362606

公开号：

AU2016362606A1

申请日:

2016.12.05

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to a modified, recombinant Factor VIII (FVIII) with extended half-life and reduced ligand-binding properties.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/