The subject of the invention is the novel crystalline forms of 1S- [1alpha (2S *, 3R *), 9alpha] 6,10-dioxo-N- (2-ethoxy-5-oxo-tetrahydro-3-furanyl) -9 [[(1-Isoquinolyl) carbonyl] amino] octahydro-6H -pyridazino [1,2-a] [1,2) diazepine-1-carboxamide anhydrous (Form A) and hydrated (Form B), process for their preparation, their application as a drug and the pharmaceutical compositions containing them.L'invention a pour objet les nouvelles formes cristallines du 1S-[1alpha(2S*,3R*),9alpha]6, 10-dioxo-N- (2-éthoxy-5 -oxo-tétrahydro-3 -furanyl)-9 [[( 1-isoquinolyl) carbonyl]amino] octahydro-6H -piridazino[1, 2-a][1 ,2]diazepine-1-carboxamide anhydre (forme A) et hydratée (forme B), leur procédé depréparation, leur application à titre de médicament et les compositionspharmaceutiques les renfermant.