COMPOSES ARYL-(IMIDAZOLE)-METHYL)-PHENYLE SUBSTITUES SERVANT DE MODULATEURS SELECTIFS DES SOUS-TYPES DES RECEPTEURS ADRENERGIQUES ALPHA 2B ET/OU ALPHA 2C

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专利权人:

ALLERGAN; INC.

发明人:

申请号：

EP09702950.8

公开号：

EP2250153B1

申请日:

2009.01.13

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

A compound having selective modulating activity at the alpha 2B and or alpha 2C adrenergic receptor subtypes is represented by the general Formula (1): wherein R1-R6 is independently selected from the group consisting of H, C1-6 alkyl, halogen, CH2OH, CH2N(R7)2) CH2CN, C(O)R8, CF3, and aryl； wherein R7 is H or C1-6 alkyl； and R8 is H, C1-6 alkyl or aryl. The compounds of Formula (1) can be incorporated in pharmaceutical compositions and used in methods of treatment of alpha 2 receptor mediated diseases and conditions.

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