KOMINOS, Dorothea,ZHANG, Jie,PRITSKER, Alla,DAVISON, Matthew,BAURIN, Nicolas,SUBRAMANIAN, Govindan,CHEN, Xin,LI, Han
申请号：
ES13715049
公开号：
ES2673869T3
申请日:
2013.03.15
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
An isolated monoclonal antibody or antigen-binding fragment thereof that specifically binds Calidin or des-Arg10-Calidine but not Bradykinin or des-Arg9-Bradykinin, wherein the antibody or antigen-binding fragment comprises: i) a variable domain of the heavy chain comprising an amino acid sequence of the region 3 determining the heavy chain complementarity (HCDR3), an amino acid sequence of the region 2 determining the heavy chain complementarity (HCDR2) and a sequence of amino acids of the region 1 determining the heavy chain complementarity (HCDR1), selected from the group consisting of: a) SEQ ID NO: 7 [X1Y X2 X3D X4HAM X5Y], wherein X1 is Y, F or H, X2 is R, D, A, V, L, I, M, F, Y or W, X3 is Y, F, W or H, X4 is D, E or Y, and X5 is D or E； SEQ ID NO: 8 [YFX1PX2NGNTGYNQKFRG], where X1 is D, R, A, V, L, I, M, F, Y or W, and X2 is Y, D, E, N or Q； and SEQ ID NO: 9 [GYSFTDYX1IY], where X1 is N, W or Y； respectively, b) SEQ ID NO: 63 [X1EYDGX2YX3X4LDX5], wherein X1 is W or F, X2 is N or no amino acid； X3 is Y or S, X4 is D or P, and X5 is F or Y； SEQ ID NO: 64 [WX1DPENGDX2X3YAPKFQG], where X1 is I or V, X2 is T or S, and X3 is G or D； SEQ ID NO: 65 [GFNIKDYYX1H], wherein X1 is L or M； respectively, c) SEQ ID NO: 13； SEQ ID NO: 14； and SEQ ID NO: 15； respectively, d) SEQ ID NO: 32； SEQ ID NO: 33； and SEQ ID NO: 34； respectively, e) SEQ ID NO: 40； SEQ ID NO: 41； and SEQ ID NO: 42； respectively, f) SEQ ID NO: 47； SEQ ID NO: 48； and SEQ ID NO: 49； respectively, and g) SEQ ID NO: 55； SEQ ID NO: 56； and SEQ ID NO: 57； respectively； and e) SEQ ID NO: 40； SEQ ID NO: 41； and SEQ ID NO: 42； respectively, f) SEQ ID NO: 47； SEQ ID NO: 48； and SEQ ID NO: 49； respectively, and g) SEQ ID NO: 55； SEQ ID NO: 56； and SEQ ID NO: 57； respectively； and X2 is S or G, X3 is N or D, X4 is K or R, X5 is H or Y； respectively, j) SEQ ID NO: 69 [X1QGTHFPYT], wherein X1 is L or M； SEQ ID NO: 36； and SEQ ID NO: 70 [KSSQSLLYSNGX1TYLN], wherein X1 is K or E； respectively, k) SEQ ID NO: 16； SEQ ID
