Yoshihiko Norimine,Kunitoshi Takeda,Koji Hagiwara,Yuichi Suzuki,Yuki Ishihara,Nobuaki Sato
申请号：
US13644745
公开号：
US08563565B2
申请日:
2012.10.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A compound and/or pharmacologically acceptable salt thereof represented by the formula (I) has PDE9 inhibitory action, so that the intracerebral cGMP concentration is anticipated to be elevated. The PDE9 inhibitory action and the increase in cGMP lead to the improvement of learning and memory behaviors, and the compound (I) has a potential use of a therapeutic agent for cognitive dysfunctions in Alzheimer's disease.wherein R1 is a hydrogen atom； R2 is an aromatic ring group, etc.； R3 is a hydrogen atom, etc； R4 is a hydrogen atom； R5 is an oxepanyl group, etc.； R6 is a hydrogen atom.
