Peter Dragovich,Zhonghua Pei,Thomas Pillow,Jack Sadowsky,Jinhua Chen,John Wai
申请号：
US15293743
公开号：
US20170112891A1
申请日:
2016.10.14
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention relates generally to disulfide drug conjugates wherein a linker comprising a sulfur-bearing carbon atom substituted with at least one hydrocarbyl or substituted hydrocarbyl is conjugated by a disulfide bond to a cysteine sulfur atom of a targeting carrier, and wherein the linker is further conjugated to a drug moiety. The invention further relates to activated linker-drug conjugates suitable for conjugation to a targeting carrier by a disulfide bond. The invention further relates to methods for preparing hindered disulfide drug conjugates.
