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Quinazoline derivatives having tyrosine kinase inhibitory activity
专利权人:
Masaharu Kume;Naoki Omori;Aiko Omori;Takeshi Endo;Kenji Matsuo;Masami Takayama
发明人:
Masaharu Kume,Kenji Matsuo,Naoki Omori,Masami Takayama,Aiko Omori,Takeshi Endo
申请号:
US13359326
公开号:
US08349857B2
申请日:
2012.01.26
申请国别(地区):
US
年份:
2013
代理人:
摘要:
A compound which inhibits both of EGF receptor tyrosine kinase and HER2 tyrosine kinase is provided.A compound represented by the general formula (I):wherein RX is a group represented by the formula:wherein R1 is a hydrogen atom, optionally substituted alkyl, etc.; Z is —O—, —N(R10)—, etc.; R10 is a hydrogen atom, alkyl, etc.; R2 is a hydrogen atom, optionally substituted alkyl, etc.; R18 is a hydrogen atom, optionally substituted alkyl, etc.; R19 is optionally substituted alkyl, etc.; W1 is an optionally substituted non-aromatic nitrogen-containing group; R17 is a hydrogen atom, optionally substituted alkyl, etc.; R3 and R4 are independently a hydrogen atom, optionally substituted alkyl, etc.; X is —O—, —S—, or —N(R12)—, etc.; R12 is a hydrogen atom, alkyl, etc.; and A is phenyl optionally having a substituent, etc.,its pharmaceutically acceptable salt, or a solvate thereof.
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