Certain embodiments of the invention relates to a transdermal drug delivery system containing donepezil or a pharmaccutically acceptable salt thereof as an active ingredient, more specifically to a transdermal drug delivery system containing a drug-containing matrix layer comprising donepezil or its pharmaceutically acceptable salt, a styrene copolymer, a hydrogenated rosin glycerol ester, and optionally a hydrocarbon resin.本發明之某些實施例係關於一種包含多奈哌齊(donepezil)或其醫藥上可接受的鹽作為活性成分之經皮藥物傳輸系統，更具體言之係關於一種含有含藥物的基質層之經皮藥物傳輸系統，該含藥物的基質層包含多奈哌齊或其醫藥上可接受的鹽、苯乙烯共聚物、氫化松香甘油酯及視情況之烴樹脂。
