A member abutting contact with the skin of a living body, while the contact member is in contact with the skin in advance, the in vivo component measurement system, skin penetration enhancement process of forming the interstitial fluid extraction site as a position relative to the contacting member collection member configured to be able and apparatus, a collecting member for collecting the tissue fluid, and holds the collecting member, the position relative to the contact member which is in contact with the skin and is attached to the interstitial fluid extraction site collection member and a measuring device for measuring components contained in the holding member, the tissue fluid collected by the collection member, at least one of the collection member holding member and the contact member, and a state of being attached to the interstitial fluid extraction site collection member at, it is separated from the skin are configured to be.この生体内成分測定システムは、生体の皮膚と当接する当接部材と、予め当接部材が皮膚に当接された状態で、当接部材を位置基準として組織液抽出部位を形成する皮膚透過亢進処理装置と、組織液を収集する収集部材と、収集部材を保持するとともに、皮膚に当接された当接部材を位置基準として、収集部材を組織液抽出部位に付着させることが可能に構成された収集部材保持部材と、収集部材に収集された組織液に含まれる成分を測定する測定装置とを備え、当接部材および収集部材保持部材の少なくともいずれか一方は、収集部材を組織液抽出部位に付着させた状態で、皮膚から離間させることが可能に構成されている。
