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NEW CATHEPSIN S PROTEASE INHIBITORS, USEFUL IN THE TREATMENT OF E.G AUTOIMMUNE DISORDERS, ALLERGY AND CHRONIC PAIN CONDITIONS
专利权人:
MEDIVIR UK LIMITED
发明人:
SUSANA AYESA,URSZULA GRABOWSKA,ELLEN HEWITT,DANIEL JONSSON,BJORN KLASSON,PIA KAHNBERG,STINA LUNDGREN,JAN TEJBRANT,DANIEL WIKTELIUS
申请号:
PH12014501958
公开号:
PH12014501958A1
申请日:
2014.09.01
申请国别(地区):
PH
年份:
2015
代理人:
摘要:
Compounds of the formula (I) wherein R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C1-C4alkoxy, or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl R3 is a C5-C10 alkyl, optionally substituted with 1-3 substituents independently selected from halo, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy or R3 is a C2-C4alkyl chain with at least 2 chloro or 3 fluoro substituents or R3 is C3-C7cycloalkylmethyl, optionally substituted with 1-3 substituents independently selected from C1-C4alkyl, halo, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy R4 is C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylamino, C1- C6dialkylamino or R4 is Het or Carbocyclyl, either of which is optionally substituted with 1-3 substituents n is 1, 2 or 3 for the use in the prophylaxis or treatment of a disorder characterised by inappropriate expression or activation of cathepsin S.
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