AYESA SUSANA,GRABOWSKA URSZULA,HEWITT ELLEN,JÖNSSON DANIEL,KLASSON BJÖRN,KAHNBERG PIA,LUNDGREN STINA,TEJBRANT JAN,WIKTELIUS DANIEL
申请号：
IN9726/DELNP/2012
公开号：
IN2012DN09726A
申请日:
2012.11.09
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
Compounds of the formula (I) wherein R2a and R2bare independently H, halo, Ci- C4alkyl, Ci-C4haloalkyl or Ci-C4alkoxy, or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl R3 is a C5-C10 alkyl, optionally substituted with 1-3 substituents independently selected from halo, Ci-C4haloalkyl, Ci-C4alkoxy, Ci-C4haloalkoxy or R3 is a C2-C4atkyl chain with at least 2 chloro or 3 fluoro substituents or R3 is C3-C7cycloalkylmethyl, optionally substituted with 1-3 substituents independently selected from Ci- C4alkyl, halo, Ci-C4haloalkyl, Ci-C4alkoxy, Ci-C4haloalkoxy R4 is Ci-Cealkyl, Ci-Cehaloalkyl, Ci-C6alkoxy, Ci-Cehaloalkoxy, Ci-C6alkylamino, Ci- C6dialkylamino or R4 is Het or Carbocyclyl, either of which is optionally substituted with 1-3 substituents n is 1, 2 or 3 for the use in the prophylaxis or treatment of a disorder characterised by inappropriate expression or activation of cathepsin S.
