Martinez Botella Gabriel,Harrison Boyd L.,Robichaud Albert J.,Salituro Francesco G.,Beresis Richard T.
申请号：
US201715639702
公开号：
US2018141971(A1)
申请日:
2017.06.30
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
Provided herein are 19-nor C3,3-disubstituted steroids of Formula (I):;;and pharmaceutically acceptable salts thereof; wherein , R1, R2, R3a, R3b, R4a, and R4b are as defined herein, and A is a carbon bound substituted or unsubstituted 5- to 6-membered heteroaryl ring as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
