РЕО Джозеф П. (US),ФАУЛЕР Кевин К. (US),КАБИР Мохаммед А. (US),ТЬЮН Майкл П. (US),НЕЛЬСОН Деннис (US),ТАЙ Анна У. (US),КИМ Нэнхи (US)
申请号：
RU2013124831/15
公开号：
RU2013124831A
申请日:
2011.10.24
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
A1. The concentrate of the solution, including (wt./mass.) (A) 37% -57% water； (b) 0.05% -0.36% sodium benzoate； (c) 42% -62% polyethylene glycol having an average molecular weight of 2680-4020 Da； and (d) a pharmaceutically acceptable acid in an amount sufficient to obtain a solution having a pH value at a temperature of 25 ° C in the range of 3.0-5.0； wherein said solution concentrate is packaged in an airtight container having a penetration rate of oxygen into a dry container of not more than 0.1 cm / container / day from air at a pressure of one atmosphere (0.1 MPa) and a temperature of 25 ° C., as measured using a standard ASTM F-1307-02.2. The solution concentrate according to claim 1, including (wt./mass.) (A) 42% -52% water； (b) 0.24% -0.36% sodium benzoate； and (c) 47% -57% polyethylene glycol having an average molecular weight of 3015-3685 Yes, wherein the pH of the solution is 3.5-5.0.3. The solution concentrate according to claim 2, in which the polyethylene glycol has an average molecular weight of 3350 Da. The solution concentrate according to claim 3, comprising about (w / w) (a) 47% water； (b) 0.3% sodium benzoate； and (c) 52% polyethylene glycol having an average molecular weight of 3350 Da. 5. The solution concentrate according to claim 3, wherein the solution concentrate is packaged in an airtight container having an oxygen penetration rate of not more than 0.1 cm / container / day from air at a pressure of one atmosphere (0.1 MPa) and a temperature of 25 ° C, moreover, the container is a bottle having a volumetric capacity of 1-50 ounces (28.4-1420 g) .6. The solution concentrate according to claim 5, wherein the container is a bottle having a volumetric capacity of 1-30 ounces (28.4-852 g), and the rate of penetration of oxygen into the bottle is not more than 0.05 cm / container / day. The solution concentrate according to claim 5, whereinА1. Концентрат раствора, включающий (масс./масс.) (а) 37%-57% воды； (b) 0,05%-0,36% бензоата натрия； (с) 42
