5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone and the intermediates for production thereof

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专利权人:

Daumantas Matulis

发明人:

Daumantas Matulis,Inga Cikotiene,Egidijus Kazlauskas,Jurgita Matuliene

申请号：

US12990551

公开号：

US08314132B2

申请日:

2008.06.18

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Invention is related to novel compounds -5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles with general formula (I). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit Hsp90 chaperone which participate in cancer progression. This invention is also related to new intermediate compounds which are used for the synthesis of thiadiazoles of general formula (I).

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