THE USA; AS REPRESENTED BY THE SECRETARY OF THE ARMY; ON BEHALF OF THE UNITED STATES ARMY MEDICAL RESEARCH
发明人:
HOOPER, JAY,GOLDEN, JOSEPH
申请号：
EP08826314
公开号：
EP2167123A4
申请日:
2008.07.07
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The invention described here encompasses DNA and protein vaccines against poxviruses, and relevant immunogenic compositions, comprising at a minimum a nucleic acid encoding a modified full-length poxvirus L1R gene or its ortholog. The L1R gene is modified so that an endoplasmic reticulum-targeting sequence is operably linked on the 5' end. Preferably the nucleic acid sequences for other poxviruses antigens are also included, such as A33R, B5R and/or A27L. These vaccines and compositions provide improved neutralizing antibody response elicited by molecular poxvirus vaccines, over known vaccines using unmodified L1R.
