Described herein are various antimicrobial glass articles that have improved strength and resistance to discoloration. The improved antimicrobial glass articles described herein generally include a glass substrate with a compressive stress layer and an antimicrobial silver-containing region that each extend inward from a surface of the glass substrate to a specific depth. In some embodiments, the compressive stress layer has a compressive stress at the surface of about 500 MPa or greater and the compressive stress decreases monotonically from the surface into the depth of the glass substrate. Methods of making and using the glass articles are also described and include forming a compressive stress layer and forming an antimicrobial silver-containing region by preferentially exchanging a plurality of silver cations in a silver-containing medium for a specific plurality of first cations ions in the glass substrate.本文所述之各式抗菌玻璃製品具有改良的強度及褪色抗性。本文所述之改良的抗菌玻璃製品通常包括具有壓縮應力層及抗菌含銀區域之玻璃基板,壓縮應力層及抗菌含銀區域各自地由該玻璃基板的表面向內延伸至特定深度。在一些實施例中,壓縮應力層在表面處具有約500MPa或更大的壓縮應力,並且壓縮應力自表面至該玻璃基板的深處單調地遞減。本文亦描述製造及使用該玻璃製品的方法,包括藉由優先將該玻璃基板中特定的複數個第一陽離子交換成含銀介質中的複數個銀陽離子,來形成壓縮應力層以及形成抗菌含銀區域。