KIM, JIN CHEUL,金辰哲,KIM, JAE-HO,金载镐,金載鎬,CHO, JUNG-HYUN,赵正贤,趙正賢,KIM, YONG IL,金用镒,金用鎰,PARK, JAE HYUN,朴宰贤,朴宰賢,WOO, JONG SOO,禹锺守,禹鍾守
申请号：
TW104116993
公开号：
TW201622705A
申请日:
2015.05.27
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention relates to a composition for a self-emulsifying drug delivery system comprising dutasteride, an oil, and a PEG-40 hydrogenated castor oil as a surfactant. The composition has following characteristics: 1) the size of formulation can be reduced by decreasing the amount of excipient, resulting in convenient drug ingestion； and 2) the composition can be emulsified in a stable emulsion state in an aqueous solution, so as to exhibit good drug dissolution stability after a long-term storage, as well as good bioavailability. The composition in accordance with the present invention can be utilized for the treatment or prevention of benign prostatic hyperplasia, prostate cancer or androgenetic alopecia.本發明關於一種用於自發性乳化藥物傳輸系統的組合物，其包含度他雄胺、一油類以及一作為一界面活性劑的PEG-40氫化蓖麻油之。該組合物具有下列特徵：(1)調配物的大小可藉由降低賦形劑的量而減少，導致方便的藥物攝取；以及(2)該組合物可在一水溶液中一安定的乳化液狀態中被乳化，以使得在長時間的儲存之後展現優良的藥物溶解安定性以及優良的生物可利用性。根據本發明之組合物可被使用於良性前列腺增生、前列腺癌或者雄性基因禿的治療或預防。
