The present invention provides compounds with anti-fungal activity useful for treatment or prevention of fungal infections in human beings or plants. The antifungal compounds are inhibitors of glucan synthase and have the formula (I) (I) wherein Z denotes a mono- or bicyclic aromatic or heteroaromatic ring system and X1 and X3 are individually selected from the group consisting of -CH and N, wherein at least one of X1 and X3 is N and X2 is selected from the group consisting of –CH2, -CH-R8 and –(C=O), wherein R8 is C1-3 alkyl and Y is selected from the group consisting of –(CH2)n-, -(CHR9)-, -(CH2)p-CR10R11- (CH2)q, -(CH2)p-(C=O)-(CH2)q and -(CH2)p-(C=O)-(CH2)q, wherein n is an integer in the range of 1 to 6, p is an integer in the range of 0 to 3 and q is an integer in the range of 1 to 4 and wherein R9 R10 and R11 individually are selected from the group consisting of C1-3-alkyl and R1 and R5 are individually selected from the group consisting of –H and halogen, wherein at least one of R1 and R5 is halogen and R2 and R4 is selected from the group consisting of –H and halogen and R3 is –NH-R6, wherein R6 is selected from the group consisting of –H, alkyl, - (C=O)-R7, -(C=O)-O-R7, - (C=O)-NH2 and –SO2-R7, wherein R7 is selected from the group consisting of –H and alkyl, or a pharmaceutically acceptable salt thereof or a prodrug thereof.Cette invention concerne des composés, ou un sel pharmaceutiquement acceptable ou un pro-médicament de ceux-ci, ayant une activité antifongique utile pour traiter ou prévenir les infections fongiques chez lhomme ou chez les végétaux. Les composés antifongiques selon linvention sont des inhibiteurs de glucane synthase et répondent à la formule (I) (I) dans laquelle Z désigne un système de cycle aromatique ou hétéro-aromatique monocyclique ou bicyclique et X1 et X3 sont individuellement choisis dans le groupe constitué par -CH et N, au moins un des X1 et X3 étant N et X2 est choisi dans le groupe constitué par -CH2, -CH-R8 et -(C=O),
