Leroy F. Liu,Yi L. Lyu,Anna M. Azarova,Johnson Y. Lau
申请号：
US14222863
公开号：
US20140235578A1
申请日:
2014.03.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Various methods for treating a patient with neoplasia are disclosed, in particular, methods using topoisomerase Ila-preferential poisons, methods using a combination of a topoisomerase Illi-preferential inhibitor and a topoisomerase II poison, and methods using a combination of a topoisomerase II poison and a proteasome inhibitor are disclosed. Novel topoisomerase Ila-preferential poisons are disclosed, particularly, several novel 13-carboline derivatives are identified. Methods for identifying the novel topoisomerase Ila-preferential poisons and methods for identifying the novel topoisomerase EP-preferential inhibitors are also provided herein.
