Obshchestvo s ogranichennoj otvetstvennostyu "Mikronidl Indastrial"
发明人:
Zvezdin Vasilij Nikolaevich,Звездин Василий Николаевич
申请号：
RU2016144039
公开号：
RU0002652567C1
申请日:
2016.11.08
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: medicine.SUBSTANCE: group of inventions relates to injection devices. Microneedic aplicator comprises a microneedic template containing more than one micro-needles, made biodegradable and carrying a drug, and a substrate. Microneedles of the matrix consist of two parts, the first part that faces the point of the microneedle is 60–95 % of the microneedle height and is made from a mixture of a carrier biodegradable agent and a drug, second part, making up the remaining height of the microneedle to the base of the microneedle, is made of a biodegradable component, as a substrate, the microneedic applicator comprises a layer made of a biodegradable component or an insoluble agent, ratio of the specific dissolution rates of a carrier biodegradable agent and a biodegradable component is 1:200,000÷950,000 respectively. In the manufacture of a microneedic applicator, microneedles of a micro needle matrix are made in two parts height long, to form the first part, a mixture of a carrier bioresorbable agent and a drug is placed in the cone-shaped mold cavities to a height of 60–95 % of these wells height, mixture is kept at a negative pressure and dehydration process is carried out at a temperature of +22÷90 °C for 8÷72 hours to form the second part, the remaining volume of the wells is filled with a biodegradable component, also it is held at negative pressure, then the process of dehydration is carried out at a temperature of +22÷90 °C for 8÷72 hours, a substrate is placed above the wells.EFFECT: group of inventions allows to reduce the reaction to a foreign body, to control the release time of a drug.22 cl, 2 dwg, 1 tblГруппа изобретений относится к инъекционным устройствам. Микроигольный аппликатор включает микроигольную матрицу, содержащую более одной микроиглы, выполненной биорастворимой и несущей лекарственное средство, и подложку. Микроиглы матрицы состоят из двух частей, первая часть, которая обращена к острию микроиглы, составляет 60-95% от высоты микроиглы и
