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MORPHOLINOPURINE DERIVATIVES, HAVING PI3K AND/OR mTOR INHIBITING ACTIVITY
专利权人:
LIMITED;DAJITI SANKIO KOMPANI
发明人:
NAKAJaMA Kijosi (JP),НАКАЯМА Кийоси (JP),SUGITA Kazujuki (JP),СУГИТА Казуюки (JP),SETOGUTI Masaki (JP),СЕТОГУТИ Масаки (JP),TOMINAGA Juiti (JP),ТОМИНАГА Юити (JP),SAITOU Masanori (JP),САИТОУ Масанори,NAKAJAMA KIJOSI,НАКАЯМА Кийоси,SUGITA KAZUJUKI,СУГИТА Казуюки,SETOGUTI MASAKI,СЕТОГУТИ Масаки,TOMINAGA JUITI,ТОМИНАГА Юити,SAITOU MASANORI,ODAGIRI TAKASI,ОДАГИРИ Такаси
申请号:
RU2011119525/04
公开号:
RU0002490269C2
申请日:
2009.10.13
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: present invention relates to organic chemistry and specifically to novel morpholinopurine derivatives of general formula,or a pharmaceutically acceptable salt thereof, where R1 and R2, each independent of each other, denote a C1-C6 alkyl group or a hydrogen atom, R3a and R3b, each independent of each other, denote a C1-C6 alkyl group which can contain three substitutes selected from a group A, or a hydrogen atom, R4 denotes a C1-C6 alkyl group or a hydrogen atom, Ra denotes a group of formula -Y-R , where Y denotes a single bond or a C1-C6 alkylene group, R5 is a C1-C6 alkyl group which can contain one, two or three substitutes selected from group A, a tetrahydrofuranyl group, a pyrrolidinyl group which contains one substitute selected from a group D, and Rb and Rc, each independent of each other, denote a C1-C6 alkyl group which contains one substitute selected from a group E, or a hydrogen atom, or Rb and Rc, together with a nitrogen atom to which they are bonded, for a 5-7-member alicyclic nitrogen-containing heterocyclic group, which is pierazine, morpholine, pyrrolidine, piperidine, homopiperazine, which can contain one, two or three substitutes selected from group E; group A: halogen atom, hydroxy group, C3-C8 cycloalkyl group and oxy group; group D: C1-C6 alkylsulphonyl group; and group E: hydroxy group, formyl group, C1-C6 alkyl group, which can contain one substitute selected from said group A, diC1-C6 alkylamino group, C1-C6 alkylsulphonylamino group, C1-C6alkylsulphonyl C1-C6 alkylamino group, C1-C6 alkylsulphonylamino C1-C6alkyl group, C1-C6alkylcarbonyl group, which can contain one substitute selected from said group A, C1-C6 alkylsulphonyl group, C1-C6 alkylamino C1-C6 alkylcarbonyl group, diC1-C6 alkylamino C1-C6alkylcarbonyl group, which can contain one substitute selected from said group A, diC1-C6 alkylaminocarbonyl group, phenylsulphonyl group and hateroaryl C1-C6 alkylcarbonyl group, where the heteroaryl is imidazolyl.
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