БОРЛАНД Мария (US),БРЕЙН Кристофер Томас (US),ДОШИ Шиванг (US),КИМ Сункиу (US),МА Цзяньго (US),МЕРТИ Джош (US),ЧЖАН Хун (US)
申请号：
RU2012148133/15
公开号：
RU2012148133A
申请日:
2011.04.12
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
A combination comprising a first agent that is an inhibitor of cyclin-dependent kinase 4 or cyclin-dependent kinase 6 (CDK4 / 6) and a second agent that is an mTOR.2 inhibitor. A combination comprising a first agent that is an inhibitor of cyclin-dependent kinase 4 or cyclin-dependent kinase 6 (CDK4 / 6) and a second agent that is an mTOR inhibitor, wherein the first agent is a compound of Formula I: or a pharmaceutically acceptable salt thereof, a C1-C5 alkyl group, a C1-C6 alkyl group, a C1-C6 alkyl group, a C1-C6 alkyl group, a C1-C6 alkyl group, a C1-C6 alkyl group, be behind is branched with one or more C1-6 alkyl or OH, L is a bond, CaC (O) or C (O) NR, and wherein L may be substituted or unsubstituted, Y is H, R, NRR, OH, or Y is part of the following group, wherein Y is CR or N, wherein is 0-3 R, and R3 is C1-6 alkyl, oxo, halogen or two or more R may form a bridged alkyl group W is CR or N R3 is H, C1-6alkyl, C1-6alkyl, C3-7cycloalkyl, C (O) C1-6alkyl, Cgaloalkyl , CalkylOH, C (O) NRR, Cyanoalkyl, C (O) R, CalkylC (O) C1-6 alkyl NRR, C1-6 alkyl C (O) OR, NRR, SOC alkyl, C1-6 alkyl Cycloalkyl, C (O) olefin, alkoxy, or OH which may be substituted or unsubstituted, unless Rne is H R4 is H or halogen each R, R, R, R, R, R, R, R, R and R are independently selected from H, Cycloalkyl, a 3-14 membered cycloheteroalkyl group,
