The present invention relates to a stable topical pharmaceutical composition comprising betamethasone or its pharmaceutically acceptable salts, indomethacin or its pharmaceutically acceptable salts and a pharmaceutically acceptable excipient, which is characterized in that the composition is essentially free of 4-chlorobenzene acid； and 5-methoxy-2-methyl-3-indoleacetic acid.La presente invención corresponde a una composición farmacéutica tópica estable que comprende betametasona o sus sales farmacéuticamente aceptables, indometacina o sus sales farmacéuticamente aceptables y un excipiente farmacéuticamente aceptable, la cual se caracteriza porque la composición está esencialmente libre de 4-ácido clorobenzoico； y 5-metoxi-2-metil-3-ácido indolacético.
