CHEN, XIAOCHENG,DENNIS, MARK,JUNUTULA, JAGATH REDDY,PHILLIPS, GAIL LEWIS,PILLOW, THOMAS HARDEN,SLIWKOWSKI, MARK X.
申请号：
CA2957148
公开号：
CA2957148A1
申请日:
2015.09.16
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention provides immunoconjugates comprising anti-HER2 antibodies and methods of using the same. An immunoconjugate is provided, which comprises an antibody and a cytotoxic agent, wherein the cytotoxic agent is a center-linked pyrrolobenzodiazepine. The immunoconjugate has the formula Ab-(L-D)p, wherein: a) Ab is the antibody of any one of claim 1 to 16； b) L is a linker； c) D is a center-linked pyrrolobenzodiazepine； and d) p ranges from 1-8.
