Methods of controlling the orientation of a toggle of a puncture sealing device are disclosed. In one example, a proximal end of a toggle of the sealing device can be trapped between a release tube and a delivery tube while the puncture sealing device is being moved into a vessel through a puncture site of the vessel. Once inserted at least one of the release tube and the delivery tube can be moved relative to the other to thereby remove the proximal end of the toggle from between the release tube and delivery tube. Subsequently at least one of the release tube and the delivery tube can be moved again relative to the other such that a distal end of the release tube abuts the toggle to thereby orient the toggle in a sealing position.
