COMPOSÉS DINUCLÉOTIDIQUES CYCLIQUES D'ACIDE NUCLÉIQUE BLOQUÉ ET LEURS UTILISATIONS

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专利权人:

Aduro BioTech, Inc.;Novartis AG

发明人:

申请号：

EP17824754.0

公开号：

EP3507367A4

申请日:

2017.07.01

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The present invention provides highly active locked nucleic acid cyclic-dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the LNA-CDNs of the present invention are provided in the form of a composition comprising one or more cyclic dinucleotides that induce human STING-dependent type I interferon production, wherein the cyclic dinucleotides present in the composition have at least one 2′, 4′ locked nucleic acids within the cyclic dinucleotide.

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中国工程科技知识中心

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http://www.ckcest.cn/home/