Control logic (110) for a power injector is disclosed, where this power injector control logic (110) includes a syringe fill protocol (114), a pressure calibration protocol (116), a pressure monitoring protocol (118), and an injection protocol (120). The power injector control logic (110) is configured to execute the pressure calibration protocol (116) on each execution of the syringe fill protocol (114). The pressure calibration protocol (116) updates the pressure monitoring protocol (118), which is executed during execution of the injection protocol (120).
