Provided are methods for reducing inflammation and allergic reactions and for reducing the severity of autoimmune disorders. The method involve administering to an individual a composition that contains recombinant α2,6-sialyltransferase (ST6Gal-1). The disclosure also provides a pharmaceutical preparation that contains recombinant ST6Gal-1 and which is suitable for administration to an individual to reduce inflammation or allergic reactions, including acute allergic reactions. A method for identifying agents capable of reducing acute allergic reactions is also provided
