CHENG, Weijun,WONG, So S,ALMEIDA, Aaron, M. AM,ROZEMA, David, B. DB,BLOKHIN, Andrei, V. AV,CARLSON, Jeffrey, C. JC,承為軍,‧黃,‧埃爾米達,‧羅澤瑪,‧布羅金,‧卡爾森
申请号：
HK16108574.9
公开号：
HK1220397A
申请日:
2016.07.19
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
The present invention is directed compositions for delivery of RNA interference (RNAi) triggers to integrin positive tumor cells in vivo. The compositions comprise RGD ligand-targeted amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or conjugate) are further covalently linked to an RNAi trigger.
