LI, Chun Sing,LI, Jian,CANG, Yong,CHEN, Shuhui,LI, Gang,XU, Xiongbin,LU, Lun
申请号:
EP15822852
公开号:
EP3169368A4
申请日:
2015.07.13
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.