Thienotriazolodiazepine derivatives active against apo A

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专利权人:

スルコメッド エルエルシー

发明人:

ケンペン ハーマン,ベラス ダニエル,スターリン バーバラ

申请号：

JP2011533714

公开号：

JP5490811B2

申请日:

2009.10.29

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The invention relates to new thienotriazolodiazepine derivatives of the formula (1) wherein R1 is CH3, R2 is CH3 or -(CH2)n-R4 or -(CH2)n-O-R4 or -(CH2)n-S-R4 wherein n is 1, 2, 3 or 4 and R4 is CH3, CH2CH3 or CH2CH2OCH3, and R3 is hydrogen or -OCH2O- or -OCH2CH2O- connected to the ortho/meta position or meta/para position of the phenyl ring； or wherein R1 and R2 are hydrogen and R3 is -OCH2O- Or -OCH2CH2O- connected to the ortho/meta position or meta/para position of the phenyl ring； and pharmaceutically acceptable acid addition salts thereof. These compounds and pharmaceutical compositions containing them are useful in the treatment and prevention of atherosclerotic artery diseases, such as myocardial infarction and stroke, and of Alzheimer's disease.

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