MODIFIED IL-2 VARIANTS THAT SELECTIVELY ACTIVATE REGULATORY T CELLS FOR THE TREATMENT OF AUTOIMMUNE DISEASES

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专利权人:

INC.;DELINIA

发明人:

GREVE, JEFFREY

申请号：

SG11201700629T

公开号：

SG11201700629TA

申请日:

2015.08.10

申请国别(地区):

SG

年份:

2017

代理人:

摘要：

The invention described herein is a novel IL-2 protein with selective agonist activity for Regulatory T cells and with an additional amino acid substitution that enable chemical conjugation with Polyethyene Glycol (PEG) that increase circulating half- life compared to the IL-2 selective agonist alone. A preferred IL-2 selective agonist variant is IL2/N88R/C125S/D109C.

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中国工程科技知识中心

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http://www.ckcest.cn/home/