MOLECULES THAT SELECTIVELY ACTIVATE REGULATORY T CELLS FOR THE TREATMENT OF AUTOIMMUNE DISEASES

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专利权人:

Delinia; Inc.

发明人:

Jeffrey Greve

申请号：

US15662633

公开号：

US20170327555A1

申请日:

2017.07.28

申请国别(地区):

US

年份:

2017

代理人:

摘要：

This invention provides for a fusion protein between an IL2αβγ Selective Agonist protein (IL2 Selective Agonist) and a IgG Fe protein. The IL2 Selective Agonist moiety provides a therapeutic activity by selectively activating the IL2αβγ form of the receptor, thus selectively stimulating Tregs. The Fe moiety provides a prolonged circulating half-life compared to the circulating half-life of IL-2 or an IL2SA protein.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/