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Liquid preparation of humanized antibody for treating IL-6-related disease
专利权人:
Ltd.;Bio-Thera Solutions
发明人:
LIN, Jian,LIU, Fan,YUE, Rui,WU, Zhihao,WANG, Shengwu,LI, Shengfeng
申请号:
AU2018374232
公开号:
AU2018374232A1
申请日:
2018.11.30
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
The present invention relates to a liquid preparation of a humanized antibody for treating an IL-6-related disease. The liquid preparation comprises 2-100 mg/ml of a recombinant humanized anti-human interleukin 6 receptor monoclonal antibody, 5-20 mM of a histidine salt buffer solution (or a buffer solution of a combination of 5-20 mM of a histidine salt and 5-20 mM of sodium acetate), 0.025-0.075% (volume ratio) of a surfactant, and 3-5% (mass-to-volume ratio) of a stabilizer and water for injection. The antibody preparation enhances the stability of the recombinant anti-human interleukin 6 receptor monoclonal antibody, prevents aggregation and degradation of the monoclonal antibody, and acid isomer increase. The preparation is applicable in stabilizing the structure and function of the humanized antibody.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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