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NOUVEAU DÉRIVÉ DE 1-2-DIHYDROQUINOLINE PRÉSENTANT UNE ACTIVITÉ DE LIAISON AUX RÉCEPTEURS GLUCOCORTICOÏDES
专利权人:
LTD.;SANTEN PHARMACEUTICAL CO.
发明人:
申请号:
EP06798171.2
公开号:
EP1944290B1
申请日:
2006.09.14
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; R 1 represents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; R 2 represents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; R 3 represents a hydrogen atom, an alkyl group, an alkenyl group or the like; R 4 and R 5 represent a hydrogen atom or the like; R 6 represents a hydrogen atom or the like; A represents an alkylene group or the like; and R 7 represents OR 8 , NR 8 R 9 , SR 8 , S (O) R 8 or S (O) 2 R 8 , wherein R 8 represents an aryl group, a heterocyclic group or the like and R 9 represents a hydrogen atom or the like.
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中国工程科技知识中心
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