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Pyridine (3,4-d) pyridine derivatives and pharmaceutically acceptable pyridine salts
专利权人:
TEIJIN PHARMA LIMITED
发明人:
申请号:
ARP160101534
公开号:
AR104789A1
申请日:
2016.05.27
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
1. Characteristic 1: a compound represented by (1) a formula or a pharmaceutically acceptable salt of the compound, [where l represents - nr83099],-O-O-SR⁵ represents a hydrogen atom or a C₁₋₆ alkyl group substituted with zero to two -OH groups, zero to two C₁₋₈ alkoxy groups and zero to six fluorine atoms; R¹ represents a C₁₋₈ alkyl group,C₃₋₁₂ cycloalkyl,(cycloquilo c8323-318321; 832221) - asphalt c83231;Isopropene-c832131-832626 of 4-12 members (4-12 members);aryl C₆₋₁₀,(Aril C) -alquilo C5-10 membered heteroaryl, (5-10 membered heteroaryl) -C₁₋₆ alkyl,C₁₋₈ alkylsulfonyl or C₁₋₈ acyl;Each group containing heteromorphic atoms represented by R1 contains one to four heteromorphic atoms selected from oxygen, sulfur and nitrogen atoms; R1 can be replaced by one to six substitutes selected from halogen atom group, which are composed of one halogen atom = = - o-oh-cn-cooh-cour8310;-R8311;a C₃₋₆ cycloalkyl group substituted with zero to two -OH groups, zero to two C₁₋₈ alkoxy groups and zero to six fluorine atoms, a 3 to 10 membered heterocyclyl group substituted with zero to two -OH groups, zero to two C₁₋₈ alkoxy groups and zero to six fluorine atoms, a C₁₋₈ acyl group substituted with zero to two -OH groups, zero to two C₁₋₈ alkoxy groups and zero to six fluorine atoms, and a C₁₋ alkoxy group ₈ substituted with zero to two -OH groups, zero to two C₁₋₈ alkoxy groups and zero to six fluorine atoms; R⁶ and R⁷,each independently represents a C₁₋₆ alkyl group substituted with zero to two -OH groups, zero to two C₁₋₈ alkoxy groups and zero to six fluorine atoms; R² represents a C₁₋₈ alkyl group,C₃₋₈ cycloalkyl,4-6 members or c832131 and 832828;-Coordination 831222;or -CONR⁹R¹⁰;e. C8321c83318328 in each group;and zero to three fluorine atoms, and zero to five fluorine atoms; R² is neither an unsubstituted C₁₋₈ alkyl, nor unsubstituted C₃₋₈ cycloalkyl, nor a trifluoromethyl group; R⁸,R8313 and r183044,each independently represents a hydrogen atom or a C₁₋₈ alkyl group;the 4 t
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