Methods and systems for producing a 3D image representation of an in vivo object that include illuminating the object with at least two separate illumination sources included in a wireless imaging device, the first of the at least two illumination sources for illuminating said object from a first side of the object and the second of the at least two illumination sources for illuminating said object from a second side of the object obtaining at least a first image and a second image of the object, whereby the first image is obtained using a first illumination source, and the second image is obtained using the second illumination source comparing between photometry measurements of reflected light intensity in the at least first and second images and constructing a 3D image representation of the object from the at least first and second images, based on said comparison.
