POLYMORPHE DU MALEATE INHIBITEUR DE DPPIV ET SON PROCEDE DE PREPARATION

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专利权人:

CHINESE ACADEMY OF SCIENCES;SHANGHAI INSTITUTE OF MATERIA MEDICA

发明人:

LIU, HONG,WANG, JIANG,LI, JIAN,LI, JIA,LI, JINGYA,JIANG, HUALIANG,LUO, XIAOMIN,CHEN, KAIXIAN

申请号：

CA3018599

公开号：

CA3018599A1

申请日:

2017.03.20

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

A polymorph of (R)-methyl-2-(3-aminopiperidin-1-yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dihydrothiophene [3,2-d] pyrimidine-6-carboxylic acid maleate and a preparation method therefor. The polymorph is a crystal having high stability and low hygroscopicity, and the crystal from is selected from among crystal form A, crystal form B and crystal form C. Furthermore, the crystal form has a strong in-vivo hypoglycemic activity and can be used for the preparation of a novel drug for the treatment or prevention of diabetes mellitus type H and/or complications of diabetes mellitus type H.

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