The present invention provides a genetically modified non-human animal model with an extended lifespan and healthy period associated with reduced tumorigenesis and tumor metastasis, extending lifespan and healthy period, reducing tumorigenesis and tumor metastasis, and Related methods of identifying active agents that prolong life span or healthy periods or reduce tumor formation or tumor metastasis. [Selection] No figure本発明は、腫瘍形成及び腫瘍転移の低減と関連している寿命及び健康な期間が延びた遺伝子改変非ヒト動物モデルと、寿命及び健康な期間を延ばす、腫瘍形成及び腫瘍転移を低減させる、並びに、寿命若しくは健康な期間を延ばす、又は、腫瘍形成若しくは腫瘍転移を低減させる活性薬剤を同定する、関連の方法を含む。【選択図】図なし
